Dou Xiaoqiu

      窦晓秋

      长聘助理教授,硕士生导师

      2019.09-至今        上海交通大学 材料科学与工程学院 助理教授
      2015.10-2019.03   德国锡根大学 物理化学系 博士后
      2009.09-2015.03 上海交通大学 材料科学与工程学院 博士

      2005.09-2009.06 中国海洋大学 材料科学与工程研究院 本科

      2016年德国“洪堡学者”

      2017年第25届先进材料年会(The 25th POLYCHAR World

      Forum  on Advanced Materials)“青年科学家”奖

      2012年教育部“学术新人”奖

 

研究方向:1. 超分子水凝胶

                  2. 手性生物材料

主要从事功能化自组装材料构建,利用微纳米结构调控细胞粘附、生长等行为,揭示界面结构及化学组分对细胞行为的作用机制。2015年至今已发表论文31篇,其中以第一作者及通讯作者在Acc. Chem. Res., Adv.Mater., ACS Nano, ACS Appl. Mater. Interfaces, Biomacromolecules等期刊上共发表论文21篇,申请专利3项。

近5年取得的主要研究成果有:

(a)利用氨基酸衍生物酰胺键间手性自组装特性,构建一系列手性超分子纳米纤维。揭示了分子手性和超分子手性在细胞铺展和分化中的协同效应。该工作发表在Acc. Chem. Res., Adv. Mater., ACS Appl. Mater. Interfaces上。

(b)利用天然玫瑰花瓣为分级结构模板,构建了一系列表面结构相同,浸润性从超亲水到超疏水梯度变化的表面,深入研究了表面浸润性对细菌粘附的影响,首次提出了细菌粘附受其表面糖蛋白粘附性质的介导。该工作发表在ACS Nano上。

(c)构建微纳米分级结构,深入研究微纳米结构对细胞粘附的影响。该部分工作在癌细胞抓捕检测,体外三维细胞微环境构建方面有广阔应用前景。就此研究结果,在国际会议及研讨会上做口头报告(2016年,波兰,第24届先进材料年会;2017年,南非,The 14th Annual UNESCO/IUPAC Workshop & Conference on Macromolecules & Materials),被同行评价对开发新型超敏感的生物诊断材料有着重要意义。该工作发表在ACS Appl. Mater. Interfaces上。

(d)构建特殊的倒金字塔型微孔,通过二维细胞培养手段即可获得三维细胞团,在体外创建三维肿瘤生物模型,为抗癌药物筛选提供了更加生理的细胞模型。就此工作,在2017年马来西亚第25届先进材料年会上做口头报告,获“青年科学家奖”。研究成果发表在Biomacromolecules上。

发表论文

[1] Dou, X. Q.; Mehwish, N.; Zhao, C. L.; Liu, J. Y.; Xing, C.; Feng, C. L.*, Supramolecular hydrogels with tunable chirality for promising biomedical applications. Acc. Chem. Res. 2020, 53, 852-862.

[2] Dou, X. Q.; Wu, B. B.; Liu, J. Y.; Zhao, C. L.; Qin, M. G.; Wang, Z. M.;  Schönherr, H.*; Feng, C. L.*, Effect of chirality on cell spreading and differentiation: from chiral molecules to chiral self-assembly. ACS Appl. Mater. Interfaces 2019, 11, 38568-38577.

[3] Dou, X. Q.; Feng, C. L.*, Amino acids and peptide-based supramolecular hydrogels for three-dimensional cell culture. Adv. Mater. 2017, 29, 1604062.

[4] Dou, X. Q.; Lu, S. Q.; Feng, C. L.*; Jiang, L., Bioinspired hierarchical surface structures with tunable wettability for regulating bacteria adhesion. ACS Nano 2015, 9, 10664-10672.

[5] Mehwish, N.1; Dou, X. Q.1; Zhao, Y.; Feng, C. L.*, Supramolecular fluorescent hydrogelators as bio-imaging probes. Mater. Horiz. 2019, 6, 14-44.

[6] Dou, X. Q.*; Li, P.; Jiang, S. Y.; Bayat, H.; Schönherr, H.*, Bioinspired hierarchically structured surfaces for efficient capture and release of circulating tumor cells. ACS Appl. Mater. Interfaces 2017, 9, 8508-8518.

[7] Dou, X. Q.; Zhang, J.; Feng, C. L.*, Biotin-avidin based universal cell-matrix interaction for promoting three-dimensional cell adhesion. ACS Appl. Mater. Interfaces 2015, 7, 20786-20792.

[8] Dou, X. Q.*; Li, P.; Schönherr, H.*, Three-dimensional microstructured poly(vinyl alcohol) hydrogel platform for the controlled formation of multicellular cell spheroids. Biomacromolecules 2018, 19, 158-166.

[9] Dou, X. Q.; Li, P.; Zhang, D.; Feng, C. L.*, RGD anchored C2-benzene based PEG-like hydrogels as scaffolds for two and three dimensional cell cultures. J. Mater. Chem. B. 2013, 1, 3562-3568.

[10] Dou, X. Q.; Zhang, D.; Feng, C. L.*, Wettability of supramolecular nanofibers for controlled cell adhesion and proliferation. Langmuir 2013, 29, 15359-15366.

[11] Dou, X. Q.; Li, P.; Lu, S. Q.; Tian, X. B.; Tang, Y. T.; Mercer-Chalmers, J. D.; Feng, C. L.*; Zhang, D., Highly directional co-assembly of 2,6-pyridinedicarboxylic acid and 4-hydroxypyridine based on low molecular weight gelators. J. Mol. Liq. 2013, 180, 129-134.

[12] Dou, X. Q.; Yang. X. M.; Li, P.; Zhang, Z. G.; Schönherr. H.; Zhang, D.; Feng, C. L.*, Novel pH responsive hydrogels for controlled cell adhesion and triggered surface detachment. Soft Matter 2012, 8, 9539-9544.

[13] Dou, X. Q.; Li, P.; Zhang, D.; Feng, C. L.*, C2-symmetric benzene-based hydrogels with unique layered structures for controllable organic dye adsorption. Soft Matter 2012, 8, 3231-3238.

[14] Dou, X. Q.; Zhao, C. L.; Mehwish, N.; Li, P.; Feng, C. L.*; Schönherr, H.*, Photoresponsive supramolecular hydrogel co-assembled from Fmoc-Phe-OH and 4,4’-azopyridine for controllable dye release. Chinese J. Polym. Sci. 2019, 37, 437-443.

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