Prof. Chuan-liang Feng received his Ph.D. from the University of Twente (the Netherlands) in 2005 and subsequently conducted postdoctoral research at Max-Planck Institute for Polymer Research in Mainz. In 2009, he joined Shanghai Jiao Tong University (SJTU). Now he is a distinguished professor in School of Material Sciences and Engineering of SJTU. His research mainly focuses on the synthesis and characterization of chiral supramolecular hydrogels and biomimetic materials. He has made significant creative contributions to the design of chiral structures in supramolecular hydrogels, the development of novel self-assembly strategies, and the exploration of chirality-related biological effects. To date, he has published more than 190 papers, including in prestigious journals

such as J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater. Adv. Funct. Mater., and holds more than 20 authorized patents. As the leading contributor, he has been honored with the Shanghai Natural Science Award (First Prize, 2022) and the Science and Technology Progress Award of the Chinese Materials Research Society (First Prize, 2024).

  Research Fields

Supramolecular Chiral Assembly and Mechanisms: Precise Control the Chirality from Molecular to Macroscopic Scale

• Multi-level Chiral Transfer Pathways
• Dynamic and Intelligent Assembly Regulation
• Interface-Induced Asymmetric Assembly

Chiral Functional Materials: For Optoelectronic and Intelligent Applications

• Chiral Optical Materials
• Chiral Liquid Crystal Elastomers and Actuators
• Chiral Sensing and Detection

Chiral Biomedical Materials: Biomimetic Design and Life Regulation

• Chiral Biomimetic Extracellular Matrices
• Chirality-Mediated Stem Cell Fate
• Chirality- assisted Drug Delivery and Chiral Biosensing
• Chiral Tissue Engineering Materials and Scaffolds

AI-Driven Chiral Materials Design

• AI-Enabled Design Principle of Chiral Assembly
• Data-Driven Machine Learning for Chiral Assembly Prediction
• AI-Guided Intelligent and Personalized Design of Chiral Biomaterials

Translation and Industrial Application of Chiral Materials

• Engineering Development of Chiral Materials and Devices
• Preclinical Research of Biomedical Materials and Devices

  Awards

• 2024      Award for Science and Technology Progress (First Prize), Chinese Materials Research Society (CMRS)
• 2022      Shanghai Natural Science Award (First Prize)
• 2020      National High-Level Talent Special Support Programs (10,000 Talents Program) - Leading Talents
• 2019      Leading Young and Middle-Aged Talents in Science and Technology Innovation, Ministry of Science and Technology (MOST)
• 2019      Richard Robert Ernst Award，International Union of Pure and Applied Chemistry (IUPAC)  
• 2019      Industry-University-Research Cooperation Innovation Award, China Industry-University-Research Institute Collaboration Association (CIUR)
• 2011      Shanghai "Oriental Scholar" Distinguished Professorship
• 2010      Shanghai "Pujiang Program" Professorship
• 2009      New Century Excellent Talents，Ministry of Education (MoE)

  Administrative Positions and Memberships

• President of Wuhu University (Anhui Province)
• Dean of SJTU Wuhu Research Institute
• Chairmen of Hydrogel Materials Branch of China Materials Research Society
• Committee member of International Polymer Characterization Forum (POLY-CHAR)
• Member of Polymer Expert Think Tank Committee
• Member of Chirality Chemistry Professional Committee, Chinese Chemical Society (CCS)
• Section Editor-in-Chief of <Gels> Journal
• Specialized Editors of Transactions of Materials Research

  Programs AND Fundings

• 2025      NSFC Key Program - Research on Chiral Biomaterials Regulating Cell Fate for Tumor Treatment
• 2025      STCSM Key Technology Research Program - Design, Preparation, and Functional Regulation of High-Adhesion and Chiral Hydrogels for Stroke Treatment
• 2024      National Key Research and Development Program, Sub-project - Key Technologies for Carrier-Drug Interaction and Construction of Drug Delivery Systems
• 2021      Joint Biomaterials R&D Center, Shanghai Kaibao Pharmaceutical Co., Ltd.
• 2020      STCSM Science & Technology Innovation Action Plan - Construction and Application Research of Chiral Hydrogel-Based Wound Healing Dressings
• 2019      SJTU STAR Plan, Key Project - Applied Research on Chiral Hydrogels for Diabetic Wound Healing
• 2018      NSFC Key Program - Biomimetic Construction of Chiral Hydrogels and Their Performance
• 2017      Shanghai Municipal Education Commission, Major Research Innovation Program - Biomimetic Chiral Hydrogel Biomaterials
• 2016      NSFC General Program - Three-Dimensional Cell Adhesion Regulated by Chiral Nanofibers
• 2015      SJTU-UM Joint Institute International Collaboration Project - Research on Inflammatory Response in Ischemia-Reperfusion Injury Based on Nanostructures
• 2013      NSFC General Program - Regulation of Bio-microstructure Photo-response and DNA Molecular Recognition
• 2012      NSFC General Program - Research on Novel Amino Acid-Based Supramolecular Hydrogel Scaffolds for Cell Culture

Representative Publications

1. Sravan Baddi, Auphedeous Y. Dang-i, Fengli Gao, Xiaxin Qiu, Chuanliang Feng*. Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications. Progress in Materials Science, 2025, 51, 101428.
2. Laiben Gao, Jinying Liu, Chao Xing, Xiaxin Qiu, Jingyi Xia, Changli Zhao, Xiaoqiu Dou, Chuanliang Feng*. Conformation-Matched Symbiotic Noncovalent Sites Facilitated Supramolecular Nanotwists Featuring both P and M Sub-Helical Domains. Angew. Chem. Int. Ed. 2025, e16712.
3. Laiben Gao, Kaikai Yang, Chao Xing, Biyan Lin, Changli Zhao, Xiaoqiu Dou, Chuanliang Feng*. Simultaneous Fabrication of P and M Helices in One-Component Chiral System by Methanol-Water Mediated Dual Assembly Pathway. Angew. Chem. Int. Ed. 2025, 64(12), e202417876.
4. Fengli Gao, Xiaxin Qiu, Sravan Baddi, Sijia He, Shuting Wang, Changli Zhao, Xiaoqiu Dou, Chuanliang Feng*. Chiral Nanofibers of Camptothecin Trigger Pyroptosis for Enhanced Immunotherapy. Angew. Chem. Int. Ed. 2025, 64(13), e202423446.
5. Juexin Huang, Jingyi Xia, Sravan Baddi, Yu Zhao, Chuan-liang Feng*. Dual-Scale Polarization Engineering of D‑Phenylalanine-Based Assemblies for High-Performance Nanogenerators. ACS Nano 2025, 19, 24884−24894.
6. Beibei Wu, Xiaoqiu Dou*, Yu Zhao, Xueqian Wang, Changli Zhao, Jingyi Xia, Chao Xing, Sijia He, Chuanliang Feng*. Chiral Supramolecular Nanofibers Regulated Tumor-Derived Exosomes Secretion for Constructing an Anti-Tumor Extracellular Microenvironment. Small 2024, 20(30), 2308335
7. Xueqian Wang, Chunxiao Cui, Xinxian Meng, Chengyao Han, Beibei Wu, Xiaoqiu Dou, Changli Zhao, Yixin Zhang*, Ke Li*, Chuanliang Feng*. Chiral Supramolecular Hydrogel Enhanced Transdermal Delivery of Sodium Aescinate to Modulate M1 Macrophage Polarization Against Lymphedema. Adv. Sci. 2024, 11, 2303495.
8. Ya Li, Yulin Wang, Qiang Ao, Xiaohui Li, Zhongbing Huang*, Xiaoqiu Dou, Ning Mu, Ximing Pu, Juan Wang, Tunan Chen, Guangfu Yin, Hua Feng, Chuanliang Feng*. Unique Chirality Selection in Neural Cells for D-Matrix Enabling Specific Manipulation of Cell Behaviors. Adv. Mater. 2023, 35, 2301435.
9. Laiben Gao, Xiaoqiu Dou*, Chao Xing, Fengli Gao, Zichao Jiang, Kaikai Yang, Changli Zhao, Chuanliang Feng*. Realizing Abundant Chirality Inversion of Supramolecular Nanohelices by Multiply Manipulating the Binding Sites in Molecular Blocks. Angew. Chem. Int. Ed. 2023, 62, e202303812.
10. Laiben Gao, Chao Xing, Xiaoqiu Dou*, Yunqing Zou, Changli Zhao, Chuanliang Feng*. Kinetic Co-assembly Pathway Induced Chirality Inversion Along with Morphology Transition. Angew. Chem. Int. Ed. 2022, 61, e202211812.
11. Shengjie Jiang, Qiang Zeng, Kai Zhao, Jinying Liu, Qiannan Sun, Kang Huang, Ying He, Xuehui Zhang, Hui Wang, Xinghua Shi, Chuanliang Feng*, Xuliang Deng*, Yan Wei*. Chirality Bias Tissue Homeostasis by Manipulating Immunological Response. Adv. Mater. 2022, 34, 2105136.
12. Na Sun, Xiaoqiu Dou∗, Zhimin Tang, Dandan Zhang, Ni Ni, Jiajing Wang, Huiqin Gao, Yahan Ju, Xiaochan Dai, Changli Zhao, Ping Gu∗, Jing Jia∗, Chuanliang Feng∗. Bio-inspired chiral self-assemblies promoted neuronal differentiation of retinal progenitor cells through activation of metabolic pathway. Bioact. Mater. 2021, 6, 990–997.
13. Fang Wang, Huibin Qiu*, Chuanliang Feng*. Wrapping Chiral Nanoribbons into Coiled and Condensed Microstructures in Supramolecular Hydrogels. Adv. Funct. Mater. 2020, 30, 2002936.
14. Yan Wei, Shengjie Jiang, Mengting Si, Xuehui Zhang, Jinying Liu, Zheng Wang, Cen Cao, Jianyong Huang, Houbing Huang, Lili Chen, Shutao Wang, Chuanliang Feng*, Xuliang Deng*, Lei Jiang, Chirality controls mesenchymal stem cell lineage diversification through mechanoresponses, Adv. Mater. 2019, 31, 1900582.
15. Jinying Liu, Feng Yuan, Xiaoyu Ma, Auphedeous Y.Dang-i, Changli Zhao, Chuntai Liu, Changyu Shen, Chuanliang Feng*. The Cooperative Effect of both Molecular and Supramolecular Chirality on Cell Adhesion, Angew. Chem. Int. Ed., 2018, 57(22), 6475-6479.
16. Fang Wang, Chuanliang Feng*. Metal-Ion-Mediated Supramolecular Chirality of L-Phenylalanine Based Hydrogels, Angew. Chem. Int. Ed., 2018, 57(20), 5655-5659.
17. Xiaoqiu Dou, Chuanliang Feng*. Amino Acids and Peptide-Based Supramolecular Hydrogels for Three-Dimensional Cell Culture, Adv. Mater. 2017, 29(16), 1604062.
18. Heekyoung Choi, Kang Jin Cho, Hyowon Seo, Junho Ahn, Jinying Liu, Shim Sung Lee, Hyungjun Kim*, Chuanliang Feng*, Jong Hwa Jung*, Transfer and Dynamic Inversion of Coassembled Supramolecular Chirality through 2D-Sheet to Rolled-Up Tubular Structure, J. Am. Chem. Soc.2017, 139(49), 17711-17714.
19. Guo-Feng Liu, Ling-Yun Zhu, Wei Ji, Chuan-Liang Feng,* Zhi-Xiang Wei, Inversion of the Supramolecular Chirality of Nanofibrous Structures through Co-Assembly with Achiral Molecules, Angew. Chem. Int. Ed. 2016, 55(7),2411-2415.
20. Guofeng Liu, Di Zhang, Chuanliang Feng*, Control of Three-Dimensional Cell Adhesion by the Chirality of Nanofibers in Hydrogels, Angew. Chem. Int. Ed. 2014, 53(30), 7789-7793.