Water Helicity-Modulated Hierarchical Inverse Chirality Transfer in Supramolecular Assembly 2026-09-30

We demonstrate that a helical water can be constructed and mediate inverse chirality transfer by rationally designing l-phenylalanine derivative (LPPF) featuring a geometrically matched carboxyl pocket for water. Our findings provide deeper insight into the complexity of chirality transfer by revealing a water-helicity-modulated inverse transfer mechanism.

Enhanced Piezoelectric Response via Transient Heterochiral Solvent–Solute Matching in Supramolecular Assembly 2026-09-11

We report a heterochiral solvent–solutematching strategy for enhancing the piezoelectricity of supramolecular nanostructures assembled from enantiomeric phenylalanine derivatives.

Sub-Stoichiometric Supramolecular Co-Assembly Strategy Enabling Efficient Chirality Transfer and CPL Amplification 2026-08-24

Conventional supramolecular co-assembly typically necessitates stoichiometric or excess guest loading to achieve effective chirality transfer, a requirement that often compromises structural fidelity and chiroptical efficiency due to inefficient stereochemical communication.

Nanocarrier chirality induced conformational optimization of glucose oxidase for boosting anticancer therapy 2026-08-17

Supramolecular chiral nanocarriers successfully immobilize GOx and realize overall conformational optimization of GOx via enhanced stereoselective binding, efficiently improving GOx catalytic activity as well as tumor therapeutic efficiency.

Programmable Helical Periodicity in Single-Component Supramolecular Nanofibers for Pitch-Regulated Cellular Response 2026-06-23

Achieving a continuous range of helical pitches, remains a formidable challenge, as conventional methods typically rely on complex multicomponent systems that suffer from chemical heterogeneity and limited predictability.