Chiral Artificial Antigen-Presenting Cells Enhancing Tumor Immunotherapy: Evasion of Macrophage Uptake through Inhibition of Ser 2025-07-26

Biomimetic artificial antigen-presenting cells (aAPCs) have emerged as a promising platform for the immune system activation and modulation. However, abundant serum proteins in the living body prefer to adsorb on the aAPC surface to form a protein corona, leading to rapid clearance of aAPCs by mononuclear phagocytes, causing inefficient tumor immunotherapy by aAPCs.

Dual-Scale Polarization Engineering of D‑Phenylalanine-Based Assemblies for High- Performance Nanogenerators 2025-07-02

Piezoelectric biomaterials hold immense potential for nextgeneration microdevices, yet their piezoelectric performance often trails behind that of conventional synthetic counterparts. This study demonstrates a dual-scale polarization strategy to significantly enhance the piezoelectric response of D-phenylalanine derivatives (D-PheAD).

Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway 2025-05-13

The differentiation and stemness maintenance of stem cells are the core topics in cell biology and regenerative medicine, involving cell fate determination, developmental regulation and tissue regeneration. Chirality is an essential factor influencing multiple biological processes, including protein interactions, stem cell development and disease pathogenesis.

Self-Sorted Chiral Nanofibrous Hydrogels for Enhanced Osteoarthritis Cartilage Regeneration 2025-03-03

Self-sorting by supramolecular assembly involving homochiral building blocks is of vital importance in life systems, which allows the coexistence of multiple species in an orthogonal complex mixture to achieve respective biological functions simultaneously. 

Chiral Supramolecular Hydrogels Regulating Both Osteoblastogenesis and Osteoclastogenesis 2025-02-05

Osteoporosis, a chronic bone disorder, poses a global threat to the health of millions of individuals. The disruption of bone homeostasis is the fundamental cause of osteoporosis.