Conformation-Matched Symbiotic Noncovalent Sites Facilitated... 2025-10-28

Living system can use homochiral blocks to simultaneously fabricate diverse structures with opposite chirality (e.g., right-handed α-helices and left-handed polyproline-II helices) for maintaining three-dimensional conformations and functions of biostructures, but realizing this process in artificial systems remains exceptional challenge due to difficulty in constructing precise noncovalent pattern for diverse chirality transfer.