Chiral injectable liquid formulations are fabricated via the co-assembly of phenylalanine-derived enantiomers, flavonoids and chitosan, to tackle the drawbacks of existing chiral nanomaterials for wound healing.
Conventional supramolecular co-assembly typically necessitates stoichiometric or excess guest loading to achieve effective chirality transfer, a requirement that often compromises structural fidelity and chiroptical efficiency due to inefficient stereochemical communication.
Supramolecular chiral nanocarriers successfully immobilize GOx and realize overall conformational optimization of GOx via enhanced stereoselective binding, efficiently improving GOx catalytic activity as well as tumor therapeutic efficiency.
Achieving a continuous range of helical pitches, remains a formidable challenge, as conventional methods typically rely on complex multicomponent systems that suffer from chemical heterogeneity and limited predictability.
A chiral supramolecular biomaterial (L-/D-phenylalanine and D-phenylalanine, L/DP) is rationally designed with defined chiral nanostructure and optical activity for hypertrophic scars (HS) therapy.
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