Metabolic Reprogramming of Neural Stem Cells by Chiral Nanofiber for Spinal Cord Injury 2025-01-22

Exogenous neural stem cells (NSCs) have great potential to reconstitute damage spinal neural circuitry. However, regulating the metabolic reprogramming of NSCs for reliable nerve regeneration has been challenging. .

Chiral Nanofibers of Camptothecin Trigger Pyroptosis for Enhanced Immunotherapy 2025-01-21

Camptothecin (CPT), a chemotherapeutic agent, demonstrates significant potential in cancer therapy. However, as a drug, CPT molecule suffers from poor water solubility, limited bioavailability, and insufficient immune response. Herein, we construct CPT nanofibers (CNF) with a right-handed chiral property via supramolecular self-assembly, which significantly overcomes the solubility barriers associated with bioavailability and improves tumor immune prognosis.

Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications 2025-01-09

Co-assembly is a key phenomenon in life, playing a significant role in various biological processes. In particular, supramolecular composite hydrogels (SMCHs) form through the incorporation of diverse functionalities via a co-assembly approach.

Chirality Evolution of Supramolecular Helices by Electron Transfer Assisted Secondary Nucleation 2024-12-16

Chirality evolution is ubiquitous and important in nature, but achieving it in artificial systems is still challenging. Herein, the chirality evolution of supramolecular helices based on L-phenylalanine derivative (LPF) and naphthylamide derivate (NDIAPY) is achieved by the strategy of electron transfer (ET) assisted secondary nucleation.

Simultaneous Fabrication of P and M Helices in One-Component Chiral System by Methanol-Water Mediated Dual Assembly Pathway 2024-11-27

The synergetic evolution of multiple chiral structures stemmed from same building units is ubiquitous in nature and vital to living systems, but achieving it in artificial systems remains a challenge. Herein, we report a methanol-water mediated dual assembly pathway strategy for simultaneous construction of P and M helices in one-component chiral system.