Chirality, 2026, 38, e70142

Meng Sun1 | Zhuowei Ren1 | Hanyue Liang1 | Jie Gao1 | Wanying Zhang1 | Fengli Gao2 | Chuanliang Feng2

Abstract: The remarkable progress in nanomedicine has opened new frontiers in boosting therapeutic efficacy and reducing off-target side effects. However, fabricating chiral nanomaterials remains challenging due to difficulties in sustaining chiral configuration stability. In this study, chiral injectable liquid formulations are fabricated via the co-assembly of phenylalanine-derived enantiomers, flavonoids and chitosan, to tackle the drawbacks of existing chiral nanomaterials for wound healing. The weakly acidic chitosan solution effectively resolved the low-solubility defect of flavonoids extracted from Scutellaria baicalensis, and the chiral transfer strategy among these co-assembled components overcomes the problem of chiral lability. The resulting chiral formulations displayed strong antioxidant and antibacterial capacities and significantly accelerated wound closure in the Staphylococcus aureus-infected chronic wound model. This research provides valuable insights for the design of herb-functionalized formulations and lays a foundation for the development of advanced chiral nanomaterials with broad applications in nanomedicine.

这篇论文报道了一种新型手性纳米制剂的构建及其在慢性伤口修复中的应用。研究者通过将苯丙氨酸衍生物对映体、黄酮类化合物（源自中药黄芩）和壳聚糖进行共组装，成功制备了可注射的手性液体配方。该策略有效解决了黄酮溶解性差和手性构型不稳定的难题，赋予材料优异的抗氧化和抗菌活性。在金黄色葡萄球菌感染的伤口模型中，该制剂显著加速了创面愈合和皮肤再生，效果优于非手性对照组。研究为开发基于中药功能化的手性纳米药物提供了新思路，展现了其在纳米医学领域的广阔应用前景。

https://doi.org/10.1002/chir.70142