Programmable Helical Periodicity in Single-Component Supramolecular Nanofibers for Pitch-Regulated Cellular Response 2026-06-23

Achieving a continuous range of helical pitches, remains a formidable challenge, as conventional methods typically rely on complex multicomponent systems that suffer from chemical heterogeneity and limited predictability.

Chirality‑Dependent Supramolecular Biomaterials Remodeling of Scar Microenvironment 2026-04-28

A chiral supramolecular biomaterial (L-/D-phenylalanine and D-phenylalanine, L/DP) is rationally designed with defined chiral nanostructure and optical activity for hypertrophic scars (HS) therapy.

Multistage Phase Programming in Fibrillated Peptide Coacervates 2026-03-18

Natural protein condensates respond to external  stresses through stimuli-triggered multistage phase transitions. Reprogramming such transitions in synthetic systems is critical for rational design of self-adaptive materials with precisely regulated stimuli-responsiveness.

In Situ Heterochiral Helix Coupling Triggered Supramolecular Evolution 2026-02-12

In situ precise matching of chiral structures (e.g., stereocomplementary pairs between secondary structures of proteins) is essential for directing the evolution of biostructures.

Translating Supramolecular Design Principles to Camptothecin for Precision and Targeted Cancer Therapy 2026-01-30

This Account highlights our group's recent advances in chiral supramolecular materials for cancer therapy, which have pioneered a supramolecular engineering approach for CPT-based treatment.